... translated to English Content analysis was performed on the data written in Persian, before translation The interview guide included a list of general questions used as a tool for initiating the interviews ... were, in some cases, transferred from the earthquake area to a specific city, and because of the inability to admit the casualties, they were referred to yet a second city“ according to another interviewee ... regarding disaster response The preparedness of the Ministry of Health in Pakistan was far from sufficient regarding the earthquake in 2005 [18] Since there was no disaster management plan during...
... new member of the team in Melbourne, Australia Use tools for creative and innovative thinking: Begin by setting aside time to brainstorm with employees and investigate innovative and creative ... compelling them to accept it, you’re likely to run into problems Employees truly buy in when they decide to invest their individual abilities and energies, as if they were business owners making ... your employees to continue to stretch, yet you want to be certain they can attain their goals This is key in staying highly motivated Next, be specific about what it’s going to take to actually...
... new member of the team in Melbourne, Australia Use tools for creative and innovative thinking: Begin by setting aside time to brainstorm with employees and investigate innovative and creative ... compelling them to accept it, you’re likely to run into problems Employees truly buy in when they decide to invest their individual abilities and energies, as if they were business owners making ... your employees to continue to stretch, yet you want to be certain they can attain their goals This is key in staying highly motivated Next, be specific about what it’s going to take to actually...
... warming will reduce biodiversity to the extent that a given ecosystem loses its ability to maintain the baseline functions that define it Maintaining these baseline functions is, in fact, integral ... in the Pit; probably between 780 Ka and Ma old Unknown Probably Irvingtonian Unknown Probably Irvingtonian Unknown Probably Irvingtonian Unknown Probably Irvingtonian Unknown Probably Irvingtonian ... in naturally varying systems Therefore they may be useful as an ecological baseline against which future changes can be measured As global warming continues into the coming decades, changes in...
... distinct from, apoptosis [9,10] Beclin 1, a class III phosphatidylinositol 3-kinaseinteracting protein [11], plays a role in promoting autophagy [12] Beclin contains a Bcl-2-binding domain which may ... serve as a point of cross-talk between the autophagic and apoptotic pathways Recently, a BH3 domain in the Bcl-2-binding domain of Beclin was shown to bind to Bcl-XL [13] Anti-apoptotic Bcl-2 ... -XL-binding domain We next investigated the control of Beclin and its binding partner, Bcl-2, on autophagic activity Beclin was the first mammalian protein described to mediate autophagy [12] Beclin...
... subscales for thinking about depressive affect in relation to a negative event [MRQ-Emots], thinking about what can be done inresponseto it [MRQ-Inst], and searching for meaning in the event [MRQ-Srch]; ... particularly sustained amygdala activity inresponseto negative stimuli These parameters interacted such that increasing all three parameters resulted in nonlinearly higher responses to negative information ... decreased inresponseto all emotional stimuli in depressed individuals who displayed increased amygdala activity 4) The clinical relevance of sustained amygdalar processing can be inferred by examining...
... expressed in tobacco protoplasts in the absence of a B chain [152] The degradation of ricin A chain is brefeldin A-insensitive and is inhibited by the proteasome inhibitor clasto-lactacystin b-lactone, ... Similar to stromal cell derived factor-2 Similar to anther ethylene-up-regulated calmodulin-binding protein ER1 Similar to growth factor protein with mutT domain GST Similar to AHB1 Putative ring zinc ... 1161 Responseto unfolded proteins in ER of plants R Urade tered into ER subdomains containing BiP Sequestration and degradation of membrane proteins is disrupted in a mutant yeast strain lacking...
... compared responses in the younger elderly to the very elderly to further gain insights into the impact of age and vaccine response We controlled for every factor for which we could obtain data ... an impact on vaccine response, including living situation (institutionalized or community living), medical history, vaccine-specific factors such as antigen dose and route of administration, as ... received a single, intramuscular dose of inactivated in uenza vaccine in our analysis Inactivated vaccines come in several forms (split, whole, and sub-unit) all of which were included in our review...
... condition inresponseto nicotine, two minutes of data with the effect of nicotine was analyzed with LZ complexity to understand the dynamics (complexity) of neural firing inresponseto nicotine exposure ... nicotine exposure (p < 0.01) for PFC intact rats Figure indicates that nicotine plays an important role in affecting the firing of DA neurons in VTA Considering that the excitatory input to VTA ... us to focus on the single, optimal dose to investigate the influence of nicotine on the dynamics of neural firings of DA neurons The body temperature was maintained at 36 to 38°C The recording...
... made to determine clinical and demographic indicators of disease activity in an effort to predict the clinical course over time [24] Colucci et al [25] measured CSF levels of protein 14-3-3 in ... Group: Clinical importance of neutralizing antibodies against interferon beta in relapsing-remitting multiple sclerosis Lancet 2003, 362:1184-1191 Chadha K, Winstock-Guttman B, Zivadinov R, Bhasi ... with only 30 to 40% of patients reported to have a good response [20,21] This may, in part, be related to the formation of anti-interferon beta neutralizing antibodies [22] In an effort to address...
... concentrations of Th1 and Th2 cytokines were assayed to determine if there were systemic differences in the inflammatory responseto brain injury Unfortunately most of the cytokines tested were not detectable ... the altered immune response present in MT-I/II-/- mice occurs in later stages of brain injury The significant findings of increased T cell infiltrate into the injury site, increased levels of ... cells in MT-I/II-/- mice at DPI than in wild type mice Leukocyte infiltration into the injury site in wild type and MT-I/II-/- mice Leukocyte infiltration into the cryolesion at 1, and DPI was investigated...
... sequence to target avb3 integrin for imaging [19,20] Because a vb integrin is expressed on both endothelial cells and monocyte/ macrophages and the inflammatory responseto ischemia is increased in ... 5) RAGE staining also supported the scan findings There was positive staining for RAGE in the ischemic sections of hindlimbs from both diabetic and non-diabetic mice, and no staining in the contralateral ... expressing aν integrin Serial sections (5 μm in thickness) obtained from the ischemic hindlimb were deparaffinized in xylene and incubated with a ν (rat anti-mouse integrin a ν , 1:100) and costained...
... retinoblastoma protein [26] CDK inhibitors (CKIs) are the negative regulators and are grouped into two families [27] The INK4 family (p15, p16, p18, p19 and p20) only bind and inactivate cyclin ... examined a protein kinase C inhibitor peptide (19–36) obtained from Calbiochem (Darmstadt, Germany), because inhibition of protein kinase C had been reported to cause abolition of TGF1 induced ... we inhibited c- Page of 12 (page number not for citation purposes) Myc function in nucleus pulposus cells using specific inhibitors The mitogenic responseto TGF1 suppressed by pathway inhibitors...
... to incorporate in a model to discriminate the physician's decision Building a model to discriminate the physician's decision to give a dose increase The first three analyses (ranking of continuous ... analyses was to evaluate which single or composite variables, combined in a model, could discriminate the treating rheumatologist's decision to give a dose increase of infliximab to RA patients ... already incorporated into the DAS28 (or are highly related to them such as CRP and 68 tender joint and 66 swollen joint count) and taking into account only those variables at week 22 This resulted in...
... characteristics up to age one year Equine Vet J 2000, 32:217-221 King KB, Opel CF, Rempel DM: Cyclical articular joint loading leads to cartilage thinning and osteopontin production in a novel in vivo rabbit ... maintain healthy cartilage with a specific protein composition according to loading demands [32,35] In contrast, inappropriate loads alter the compositional properties of cartilage, leading to ... is a pro-apoptotic factor [54,55] Interestingly, we have not observed differences in the percentages of apoptotic cells between maximum- and minimum-weight-bearing regions in OA or in normal hips,...
... been included in double-blind clinical trials before inclusion in the present study (1 in a Golimumab versus placebo trial, in a MapKinase inhibitor versus placebo trial, and in a TNF-converting ... immune responses) is associated with poor clinical responseto therapy, thereby providing clinicians with potential tools to identify these patients prior to initiation of adalimumab treatment Finally, ... in paraffin for histological and immunohistochemical analyses Serial histological sections were stained with hematoxylin and eosin and analyzed by two observers (CG and IT) who were blinded to...
... identical to and reflects that in the plasma, both under normal conditions and in noninflammatory and inflammatory types of arthritis, excluding those associated with infections [12] To our knowledge, ... proteins [18], to promote cell death [19], and to alter the regulation of transcription factors such as activator protein-1 [20] and NF-κB [21] that are involved in cartilage degradation and joint ... contributes to cartilage degradation in late OA In another study, exposure to either low or high glucose concentrations induced insulin-like growth factor-1 The aim of the present study was therefore to...
... process involving a nuclear actin:myosin motor function Nuclear myosin 1β is required for chromosome territory repositioning in HDFs placed in low serum In an effort to elucidate which myosin isoform ... growth factor removal may be elicited through a nuclear motor such as the actin/myosin motorcomplex, containing nuclear actin and nuclear myosin I, previously shown to be involved in intranuclear ... phalloidin oleate (inhibitors of actin polymerisation) (a, b) and BDM and jasplakinolide (inhibitors of myosin polymerization) (c, d) before and during incubation in low serum for 15 minutes The...